Live from the basement of Sci Li– It’s neuropharmacology!
Background:
PCP (phencyclidine) and ketamine are noncompetitive NMDA receptor antagonists whose effects mimic some of the symptoms of schitzophrenia. PCP has been described to me as LSD’s evil psychotic twin. Ethanol/ethyl alchol is b33r.
Sooo…
“At higher doses, these drugs are disassociative anesthetics. Many are used predominantly in veterinary practice; however, ketamine has been used successfully as a pediatric anesthetic because children are less likely than adults to exhibit psychotic-like side effects. Interestingly, doses of ethanol associated with the upper range of intoxication in humans exert effects on NMDA receptors that are similar to those produced by phencyclidine and related drugs.“
Keep that in mind the next time you set out to get wasted.
as has alcohol…
as has alcohol…
Which is why ketamine has been used as a predatory/date rape drug for years…
Which is why ketamine has been used as a predatory/date rape drug for years…
Thanks Nestler, Hyman, and Malenka pg 149-150!
Thanks Nestler, Hyman, and Malenka pg 149-150!
blackout…
blackout…